Central chemoreceptors located in the medulla provide feedback to increase the rate and depth of breathing when they sense:

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Multiple Choice

Central chemoreceptors located in the medulla provide feedback to increase the rate and depth of breathing when they sense:

Explanation:
Central chemoreceptors in the medulla monitor the pH of the cerebrospinal fluid, which reflects arterial CO2 levels. When CO2 increases, it diffuses into the CSF and forms carbonic acid, lowering pH. The rise in hydrogen ion concentration in the CSF stimulates the medullary respiratory centers to increase both the rate and depth of breathing, blowing off CO2 and raising CSF pH back toward normal. They respond primarily to CO2-derived changes in pH, not to oxygen levels, which is why the drive to breathe is triggered by slight increases in CO2 or a decrease in CSF pH.

Central chemoreceptors in the medulla monitor the pH of the cerebrospinal fluid, which reflects arterial CO2 levels. When CO2 increases, it diffuses into the CSF and forms carbonic acid, lowering pH. The rise in hydrogen ion concentration in the CSF stimulates the medullary respiratory centers to increase both the rate and depth of breathing, blowing off CO2 and raising CSF pH back toward normal. They respond primarily to CO2-derived changes in pH, not to oxygen levels, which is why the drive to breathe is triggered by slight increases in CO2 or a decrease in CSF pH.

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